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United States. Type keyword s to search. Each of these isoforms is capable of inducing mitochondrial fragmentation, however one exon arrangement termed Drp1-x01 can also bind to microtubules within the cell.

Characterization of the Drp1-x01 isoform at both the RNA and protein level indicate an important, yet incompletely characterized, role in immune system biology.

Drp1 is capable of interacting with several proteins localized at the OMM. Among these, mitochondria fission factor Mff has been implicated in the formation of Drp1 spirals and the eventual fragmentation process.

Mff contains four alternatively spliced exons as well as several phosphorylation sites identified through nonbiased phosphoproteomic screens.

Inclusion of alternative exons to the Mff structure decreases its ability to recruit Drp1 from the cytosol, while phosphomimetic substitutions to conserved serine residues enhances the DrpMff interaction.

Taken together, this suggests that regulation of mitochondrial fragmentation occurs at the pretranslational alternative splicing and the posttranslational phosphorylation level is critical for maintaining the complex, yet essential, balance between mitochondrial fission and fragmentation.

Wilson, Theodore James. Cell Biology Commons.

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Characterization of the Drp1-x01 isoform at both the RNA and protein level indicate an important, yet incompletely characterized, role in immune system biology.

Drp1 is capable of interacting with several proteins localized at the OMM. Among these, mitochondria fission factor Mff has been implicated in the formation of Drp1 spirals and the eventual fragmentation process.

Mff contains four alternatively spliced exons as well as several phosphorylation sites identified through nonbiased phosphoproteomic screens.

Inclusion of alternative exons to the Mff structure decreases its ability to recruit Drp1 from the cytosol, while phosphomimetic substitutions to conserved serine residues enhances the DrpMff interaction.

Taken together, this suggests that regulation of mitochondrial fragmentation occurs at the pretranslational alternative splicing and the posttranslational phosphorylation level is critical for maintaining the complex, yet essential, balance between mitochondrial fission and fragmentation.

Wilson, Theodore James. Cell Biology Commons. Advanced Search. All rights reserved. Skip to main content Iowa Research Online. Theses and Dissertations.

Title Taking shape : regulating mitochondria morphology through alternative splicing and phosphorylation of fission factor proteins.

Where an Indian child is a ward of a tribal court, the Indian tribe shall retain exclusive jurisdiction, notwithstanding the residence or domicile of the child.

If the identity or location of the parent or Indian custodian and the tribe cannot be determined, such notice shall be given to the Secretary in like manner, who shall have fifteen days after receipt to provide the requisite notice to the parent or Indian custodian and the tribe.

No foster care placement or termination of parental rights proceeding shall be held until at least ten days after receipt of notice by the parent or Indian custodian and the tribe or the Secretary: Provided, That the parent or Indian custodian or the tribe shall, upon request, be granted up to twenty additional days to prepare for such proceeding.

The court may, in its discretion, appoint counsel for the child upon a finding that such appointment is in the best interest of the child.

Where State law makes no provision for appointment of counsel in such proceedings, the court shall promptly notify the Secretary upon appointment of counsel, and the Secretary, upon certification of the presiding judge, shall pay reasonable fees and expenses out of funds which may be appropriated pursuant to the Act of November 2, 42 Stat.

The court shall also certify that either the parent or Indian custodian fully understood the explanation in English or that it was interpreted into a language that the parent or Indian custodian understood.

Any consent given prior to, or within ten days after, birth of the Indian child shall not be valid. Upon a finding that such consent was obtained through fraud or duress, the court shall vacate such decree and return the child to the parent.

No adoption which has been effective for at least two years may be invalidated under the provisions of this subsection unless otherwise permitted under State law.

The child shall also be placed within reasonable proximity to his or her home, taking into account any special needs of the child.

In any foster care or preadoptive placement, a preference shall be given, in the absence of good cause to the contrary, to a placement with—.

Where appropriate, the preference of the Indian child or parent shall be considered: Provided, That where a consenting parent evidences a desire for anonymity, the court or agency shall give weight to such desire in applying the preferences.

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